우리 연구실에서 "Neuromodulation of inhibitory control using phase-lagged transcranial alternating current stimulation"이라는 제목으로 진행한 연구가, 재활 분야 상위 5% 국제 학술지인 Journal of NeuroEngineering and Rehabilitation에 게재되었습니다.
논문 링크: https://doi.org/10.1186/s12984-024-01385-y
위상차(phase-lag)를 두어 뇌를 비침습적으로 교류 자극을 주어서, 억제 제어(inhibitory control) 기능을 조절하는 결과를 얻었고, 관련된 뇌파(EEG)의 변화를 분석한 연구입니다.
ABSTRACT Transcranial alternating current stimulation (tACS) is a prominent non-invasive brain stimulation method for modulating neural oscillations and enhancing human cognitive function. This study aimed to investigate the effects of individualized theta tACS delivered in-phase and out-of-phase between the dorsal anterior cingulate cortex (dACC) and left dorsolateral prefrontal cortex (lDLPFC) during inhibitory control performance. The participants engaged in a Stroop task with phase-lagged theta tACS over individually optimized high-density electrode montages targeting the dACC and lDLPFC. We analyzed task performance, event-related potentials, and prestimulus electroencephalographic theta and alpha power. We observed significantly reduced reaction times following out-of-phase tACS stimulation, accompanied by reduced frontocentral N1 and N2 amplitudes, enhanced parieto-occipital P1 amplitudes, and pronounced frontocentral late sustained potentials. Out-of-phase stimulation also resulted in significantly higher prestimulus frontocentral theta and alpha activity. These findings suggest that out-of-phase theta tACS potently modulates top-down inhibitory control, supporting the feasibility of phase-lagged tACS to enhance inhibitory control performance.
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